Thromboxane
- Thromboxane
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Les thromboxanes sont des hormones à effet vasoconstricteurs. Elles engendrent une augmentation de la pression artérielle. Elles activent aussi l'agrégation des plaquettes et aident à la coagulation sanguine et au thrombus ou caillot sanguin d'où elle tire son appellation. Elles sont en équilibre homéostatique dans l'appareil circulatoire avec les prostacyclines.
Les thromboxanes appartiennent à une sous-catégorie des eicosanoïdes.
Voie de biosynthèse
Enzymes et substrats associés à la synthèse de la thromboxane et de la prostacycline
Elles sont produites dans les thrombocytes (plaquette) par l'enzyme appelée thromboxane-A synthétase à partir des endoperoxides, les prostaglandines,elles-mêmes produites par la cyclo-oxygénase (COX ou plus précisément prostaglandine H2 synthase qui possède un domaine COX ie CycloOXygénase) à partir de l'acide arachidonique (arachidonate).
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Thromboxane — is a member of the family of lipids known as eicosanoids. The two major thromboxanes are thromboxane A2 and thromboxane B2.Thromboxane is named for its role in clot formation (thrombosis).ProductionIt is produced in platelets by thromboxane A… … Wikipedia
thromboxane — [thrämbäk′sān] n. [ THROMB(O) + OX(Y) + ANE] any of various derivatives of prostaglandins, which form on blood platelets and, usually, cause blood clots and constrict blood vessels: Cf. PROSTACYCLIN … English World dictionary
Thromboxane A2 — Chembox new ImageFile = Thromboxane A2 acsv.svg ImageSize = IUPACName = OtherNames = Section1 = Chembox Identifiers CASNo = 57576 52 0 PubChem = 5280497 SMILES = MeSHName = Thromboxane+A2 Section2 = Chembox Properties Formula =… … Wikipedia
Thromboxane B2 — Chembox new ImageFile=Thromboxane B2.svg ImageSize=250px IUPACName= OtherNames= Section1= Chembox Identifiers CASNo=54397 85 2 PubChem=5283137 SMILES= MeSHName=Thromboxane+B2 Section2= Chembox Properties Formula=C20H34O6 MolarMass=370.48 g/mol… … Wikipedia
thromboxane — The formal parent of the thromboxanes; prostanoic acid in which the –COOH has been reduced to –CH3 and an oxygen atom has been inserted between carbons 11 and 12. * * * throm·box·ane thräm bäk .sān n any of several substances that are produced… … Medical dictionary
Thromboxane-A synthase — 1 (platelet, cytochrome P450, family 5, subfamily A), also known as TBXAS1, is a human gene.cite web | title = Entrez Gene: TBXAS1 thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A)| url =… … Wikipedia
Thromboxane receptor — The thromboxane receptor is a protein on the surface of cells in the endothelium of blood vessels and in the placenta which interacts with the eicosanoid lipid thromboxane. It is a G protein coupled receptors coupled to the G protein Gq.cite… … Wikipedia
thromboxane-A synthase — throm·box·ane A syn·thase (throm bokґsān sinґthās) [EC 5.3.99.5] an enzyme of the isomerase class that catalyzes the conversion in platelets of prostaglandin G2 to thromboxane A2, a potent vasoconstrictor and platelet agonist. Deficient … Medical dictionary
thromboxane — noun Etymology: thromb + ox + ane Date: 1975 any of several substances that are produced especially by platelets, are formed from endoperoxides, cause construction of vascular and bronchial smooth muscle, and promote blood clotting … New Collegiate Dictionary
thromboxane — /throm bok sayn/, n. Biochem. a compound, C20H32O5, formed in blood platelets, that constricts blood vessels and promotes clotting. [1935 40; THROMB + OX + ANE] * * * … Universalium
Thromboxane A2
