Tégafur

Tégafur
Tégafur
structure de l'énantiomère R du tégafur (à gauche) et S-tégafur (à droite)
structure de l'énantiomère R du tégafur (à gauche) et S-tégafur (à droite)
Général
Nom IUPAC 5-fluoro-3-(tétrahydrofuran-2-yl)pyridine-2,6(1H,3H)-dione
SMILES
InChI
Propriétés chimiques
Formule brute C9H10FNO3  [Isomères]
Masse molaire[1] 199,179 ± 0,009 g·mol-1
C 54,27 %, H 5,06 %, F 9,54 %, N 7,03 %, O 24,1 %,
Unités du SI & CNTP, sauf indication contraire.

Le tégafur est un produit utilisé pour la chimiothérapie et il est un composé synthétique analogue des bases pyrimidiques. Il est utilisé dans le traitement du cancer colo-rectal métastasique en association avec l'uracile. Il est métabolisé par l'organisme en 5-fluorouracile (5-FU), qui est la molécule active.

Notes et références

  1. Masse molaire calculée d’après Atomic weights of the elements 2007 sur www.chem.qmul.ac.uk.

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Contenu soumis à la licence CC-BY-SA. Source : Article Tégafur de Wikipédia en français (auteurs)

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  • tegafur — teg·a·fur (tegґə fər) an investigational cancer chemotherapeutic agent, which is 5 fluorouracil (5 FU) attached to a tetrahydrofuran moiety analogous to the ribose and deoxyribose moieties in the active metabolites of 5 FU. It acts like …   Medical dictionary

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  • Ftorafur — A substance being studied in the treatment of some types of cancer. It is a combination of tegafur and uracil. The tegafur is taken up by the cancer cells and breaks down into 5 FU, a substance that kills tumor cells. The uracil causes higher… …   English dictionary of cancer terms

  • UFT — A substance being studied in the treatment of some types of cancer. It is a combination of tegafur and uracil. The tegafur is taken up by the cancer cells and breaks down into 5 FU, a substance that kills tumor cells. The uracil causes higher… …   English dictionary of cancer terms

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